When Stan forgets his anniversary, he arranges to have 20 hours of Francine's memory erased, but the CIA temp on duty accidentally erases 20 years. Francine, having reverted to her wild child days, moves into her old apartment with Hayley as a roommate, and ends up going to a festival with Hayley's boyfriend. Meanwhile, Steve asks a good-looking girl out, but needs his wingman, Roger, to "jump on a grenade" for him and date her ugly cousin.

After Mort bowls a perfect game, and Quagmire gets a key to the city by performing CPR, Peter notices he has nothing of which to be proud. He then attempts to achieve fame by setting the world record for most nickels swallowed. However, a slight miscalculation leaves him blind with nickel poisoning.

Meredith grows increasingly dissatisfied with the unknown details of Derek's life. Meanwhile, Alex treats Devo, a patient whose religious beliefs jeopardize her chances for recovery; Izzie contemplates reconnecting with her estranged mother; Zoey, a pregnant woman in her 40s who's been diagnosed with cancer, disagrees with Cristina's medical advice; and the interns are mystified by Cable, a patient who's being treated for seizures and who thinks he's psychic.

Flanders rents a room to two college girls who, without his knowledge, use the spare room to broadcast live softcore pornographic web videos of themselves.

Bart gets expelled from school and transfers to a Catholic school, where a hip priest named Father Sean tries to convert Bart and Homer to Catholicism, which worries Marge when she believes that Catholics do not go to the same heaven as Protestants and discovers that Catholic women do not use birth control.