A sexually transmitted disease breaks out and affects several members of the hospital staff. Chief Webber promptly calls a meeting. Meanwhile, the chief reluctantly tells Dr. Derek Shepherd about his own medical concerns. Izzie and Cristina worry about a patient's wife and daughter who can't agree on his care. Burke treats his college buddy Bill, whose medical diagnosis raises some questions regarding his wife's actions. Then just as Meredith and Derek grow more intimate, a surprise is revealed.

Jeremy puts the 4 door Mercedes CLS to the test and likes it. The Stig takes the AMG Mercedes CLS around the Top Gear track for a power lap. James likes the Honda Element, which is not sold in the UK.Richard and James play 5-a-side Aygo football and the new Range Rover Sport goes head-to-head with a Challenger II tank. James Nesbitt is the Star in a Reasonably Priced Car.