Nick takes the lead on a case where in the house a family of four, three pools of blood are found. Nick thinks that the little girl may still be alive, but Sara is doubtful, thinking that Nick's recent near-death experience is affecting his judgement.
Houston Astros pitcher (and 2006 NLCS MVP) Roy Oswalt presents the Top Ten; with a little help from Dave, Madonna rides a horse for the first time since a much-publicized incident two months earlier; Melissa Etheridge performs "I Run For Life."