Steve becomes a famous author, and the entire family gets caught up in his celebrity, including Stan, who becomes an unbearable "stage parent." After Steve hooks up with an agent, he abandons his family to lead a "Cribs" lifestyle.

Lois discovers she has a brother named Patrick and takes the family cross-country to meet him. It turns out; he’s locked up in a mental institution. Lois thinks he’s sane, so she checks him out to live with the Griffins. Meanwhile, Peter starts the Society for the Acceptance of Fat Men. But when all the fat men of Quahog are strangled one-by-one the group lives in fear. Who could the “Fat Man Strangler” be?

Dorie Russell is waiting for quintuplets, all 5 girls. Her husband seems more concerned than she is but she is set to bring her babies to their term of 36 weeks. All the departments are on call for the quintuplets as three of them have developped problems of different kinds. Meredith last night's stand shows up at the hospital with priapism and they need to call Derek Sheperd for a consult which puts Meredith in a very embarassing position. Alex and Derek must take care of a patient who has a tumor inducing thirst as a side effect. On the love side, Alex and Izzie are having some slight sexual problems, while Meredith goes on adding one night stands and Cristina is thrown off course by being "keyed."

The mayor’s estate is used for Springfield’s Easter celebration, and in the course of the events, Homer embarrasses Marge in front of some new potential friends. To make it up, Homer decides to find her some new friends, with little luck. Marge finds some new friends on her own, Tammy and other members of “The Cheery Red Tomatoes,” a group of women of a certain age. This group has plans for a fund raiser; they intend to rob Mr. Burns of 1 million dollars, an amount he once promised to charity. Homer finds out about the plan and tries to stop her from doing something she’ll regret. Meanwhile, Lisa in search of summer opportunities decides to spend the summer in Rome. Lisa tells Principal Skinner that she speaks fluent Italian, since she really doesn’t she tries to take a crash course and winds up hiring a tutor that turns out to be Milhouse.

The boys are off on a continental road trip to visit the Millau Viaduct in France in their favourite supercars: Richard drives a Pagani Zonda; James drives a Ferrari F430 and Jeremy drives his own Ford GT. Jeremy also drives the 'air-hostess orange' Focus ST on the track.