Cristina Yang has little sympathy for Constance Ferguson (special guest star Rosanna Arquette), a prison inmate who jeopardizes her health just to get out of solitary confinement. Meanwhile the interns all keep careful watch on the family of premature quintuplets with a variety of serious health challenges, Izzie's anger at Alex reaches boiling point, and Dr. Addison Shepherd decides to teach Izzie a very painful lesson.

This week, the challenge is set to try and buy a "decent" mid-engined supercar for under £10,000. Richard drives the Marcos TSO GT2 and there's a race through Lisbon between a car and a mountain bike. Dame Ellen MacArthur is this week's Star in a Reasonably Priced Car.