After receiving a hefty bonus from work, Stan buys extravagant gadgets while Francine pleads for her dream kiosk. Upset about his lack of support, Francine opens a muffin shop without his approval and gives Stan a taste of life without a housewife. In a desperate move, Stan puts Klaus' brain back into a human body – only to discover it was a huge mistake as Klaus tries to win over Francine. Meanwhile, Steve is convinced he's a teen wolf after watching a horror film.

At his high school reunion, Peter tries to impress his fellow classmates. When Peter, heading for the bathroom, charges through the crowd of people, impresses quarterback Tom Brady, who offers Peter a spot on the New England Patriots. Meanwhile, Brian owes Stewie money, after Stewie becomes a sports bookie.

All the nurses at Seattle Grace Hospital go on strike, leaving the doctors to fend for themselves. George refuses to cross the picket line and finally joins the nurses on their strike while Alex, Cristina, Izzie and Meredith meets Bailey's stand-in: Dr. Cindy Aaron, the complete opposite of Miranda Bailey. Izzie agrees to work on a difficult pregnancy case with Addison, while Cristina and Alex are in the pit attending to a young married woman with a real bad case of rash. Meredith happens on an old woman that she needs to intubate and then learns she was DNR.

Bart obtains the key to the steam tunnels under the school and with Milhouse they go down to check them out. When Bart turns just one of the little valves they find in the valve room the chain reaction causes chaos throughout the school. Bart is caught and Skinner wants to send him to a discipline camp in Oregon. When Bart can’t fly there alone, Homer has to drive him there himself and that is going to cause him to miss the trip to Las Vegas that Moe is sponsoring for all his regular customers. While the boys are gone, Marge and Lisa take some of the boys' old stuff and hold a yard sale, but the only things that sell well are their old medications and that gets her into bit of trouble.