Because of a past incident at his own prom, where he was lured into a dance with the homecoming queen only to have a pile of pigs dropped on him, Stan wants revenge by showing off that he married a homecoming queen, Francine. A proud Stan accompanies Francine to her reunion, but when they find out that two ballots were lost and that Francine didn’t actually win the crown, Stan is devastated. Meanwhile, a dejected Steve is “saved” by a pizza delivery man with a Messianic message.

Meredith and George are experiencing morning-after tension at home and at work and it has the rest of the doctors wondering what's up. Derek and Addison are experiencing their own version of morning-after tension as a result of Mark's visit to Seattle. Bailey, returning the favor that was done for her during the Code Black situation, must treat Addison for a specific feminine problem. Izzie and Alex are making headway in their relationship until Denny Duquette comes back. Soon Alex is not-so-oddly jealous of the attention Izzie is showing to Denny. Someone finds comfort in confiding in a patient who is going through an ordeal of his own. Burke deals with a patient and gets to observe the patient's unstable relationship with his fiancée.

Mr. Krupt is the school’s new gym teacher and introduces Bart and the kids to “BOMBARDMENT!” Bart’s attempt to get back at the new gym teacher results in the destruction of Groundskeeper Willie’s shack and the family takes him in. Lisa decides to make Willie the focus of her science fair project and tries to turn him into a “proper gentleman” with surprising results. Meanwhile, Homer has ruined his last pair of blue pants and attempts to generate interest in them so the manufacturer will start making them again.