When Peter wins a maid for a week as a prize on a game show, Quagmire gains an interest in her, and they eventually marry. Quagmire, stricken with his bachelor ways, tries to get out of the marriage. Meanwhile, Lois stops breast-feeding Stewie, who, as a result, goes through withdrawals.

The doctors are up to their necks in their usual levels of drama. Meredith is dealing with the backlash of sleeping with George, George and Burke are bonding in ways that bother and creep out Cristina, Cristina gets stuck on diaper duty, Bailey gets involved in a case even though she's still supposed to be on maternity leave, Addison and Derek have a talk, and Izzie is still flaking on Alex for Denny Duquette, the heart patient who didn't get a heart. In the patients-of-the-week department we've got a very pregnant woman, a hockey player who desires medically unnessasary amputation, and a woman with a fork in her neck who happens to be dying and has a struggling marriage.

The family is on a nature walk through “Carl’s Dad Caverns,” when Homer tries to get a piece from a stalactite. This results in the family falling through the cave floor and winds up with Homer getting stuck in the ceiling of one of the lower chambers of the cave. Marge, Bart and Maggie go off to find help, while Lisa stays behind and tells her father a story to pass the time. Her story involves running from a bighorn sheep and into Mr. Burn’s mansion. The pair evades the tenacious sheep by finding refuge in the mansion’s attic, where Mr. Burns tells her the story of how he came to work at Moe’s Tavern by losing a scavenger hunt with a rich Texan. While there he learned (and tells to Lisa) the tale of the Moe’s treasure. The stories within stories culminate in the fate of the treasure being determined in the cave.