After a series of deaths at the hospital some of the staff become very superstitious. Izzie worries about Denny and gets confronted by Alex. A patient with OCD drives Cristina crazy. Derek and Addison discuss their relationships with Meredith. Richard treats a friend from 17 years ago who reveals a secret about a dark time in his past that involves Ellis. George gets an earful about the women he's not talking to. Burke and Cristina argue about kicking George out.

The family is at a church fund-raiser, where Homer tries to ensure his rubber duck onto victory, but Flanders wins the big prize, which he doesn’t want and gives it to Marge. In return Marge agrees to watch Rod and Todd while Ned is attending a left-handed convention. While Marge is spending all her time with the Rod and Todd and trying to let them learn how to be boys; Homer takes Bart and Lisa to a home for former celebrity animals and a monkey kidnaps Bart. Marge’s ability to be a mother comes into question when Ned discovers what she is doing with his boys and the local news covers Bart’s current predicament.