Meredith and Izzie take up knitting. Derek operates on Andrew, a spelling bee champ with a serious head injury. Bailey gets in on Andrew's surgery because she's worried that her coworkers won't recognize her Nazi-status now that she's a mother. Addison's patient has an unborn baby with medical issues. After Alex fails to bite his tongue when a terminal patient routinely lies to her daughter about her health he gets a lesson in bedside manners from Burke. George also begins to overstay his welcome at Burke's apartment after Callie visits him. Meredith has more confusing and uncomfortable encounters with members of her family. One of the female doctors meets a veterinarian named Finn. Izzie flirts with Denny and they play more naughty-Scrabble. Meredith, Derek, and Addison sarcastically take another small stab at their friendships.

Homer spearheads the effort to get pro-football to bring a new franchise to Springfield. The football commissioner, on his way to officially award the franchise, stops at the Simpson house where Grandpa (mistaking him for a burglar) attacks him. Springfield loses out and Abe becomes the town’s pariah. After trying and failing assisted suicide, Abe decides to live his life without fear and when the town decides to reuse their football stadium as a bullfighting ring, he volunteers to be the toreador. Ever the activist, granddaughter Lisa protests his new profession.