When Francine's birthday brings back haunting memories of a celebrity film moment stolen by George Clooney, Francine's new dream is to destroy the star. But when she tries to win Clooney's heart with the intention of breaking it, Stan actually falls for him and sabotages the plan. Meanwhile, back at home, Roger builds a vineyard and starts up a private sweat shop of foster children.
When burglars break into the house, the Griffins take cover in the attic where they discover Peter has built a 'panic room'. They go in it, and Peter tells them about his history. They send Meg for food but the burglars catch her. The rest of the Griffins stay behind and Peter accidentally floods the room and they're going to drown. Luckily Joe gets them out and we find out Meg has been accused of sexual harassment by the burglars.
George and Derek work together, Denny still doesn't have a heart, and Meredith gets paired with Callie. A 12-week pregnant girl dies in the O.R. and her parents try to keep the baby alive. This causes tension between Derek and Addison. One doctor's overreaction unites two bickering patients. Finn is still treating Doc for medical problems.
Working through their checklists of things to do before summer ends, Lisa gets the family to go a museum. At the Springfield Museum of Natural History there is an exhibit Lisa is excited to see on Women’s History turns into an exhibit on the history of weapons, which excites Homer and Bart. When Flanders sees the exhibit of evolution and another that mocks creationism, he raises an alarm. Reverend Lovejoy gets Skinner to have creationism taught in school. Lisa is the only one who holds onto the scientific theory. She brings the topic up at the town meeting and the town votes to teach only one theory, creationism. Lisa decides to hold her own class on evolution, until she is arrested. The ACLU gives her a lawyer who is up against a slick Southern lawyer, but ultimately it’s a family member that is a key to her defense.
Part 1 of two. The tension boils over when the three remaining chefs journey to Las Vegas to compete in a room-service challenge. Chef Hubert Keller serves as a guest judge.
The Jaguar XK is driven by Jeremy through the spectacular scenery of the Yorkshire Dales. He also drove the new Corvette Z06. Richard was in Iceland for a race against a jet-powered kayak - he drove the Tomcat 4x4. In Brighton, Jeremy, James and Richard took over a live drivetime radio programme on BBC Southern Counties Radio and were rubbish at it. Gordon Ramsay is the Star in a Reasonably Priced Car.