Grissom attempts to get a confession from a neighborhood pedophile by having him help in locating two missing boys. The sex offender is the main suspect. The investigation is more complex than the team ever thought it would be.

Cristina gets to scrub in on a rare surgery which incites envy. Alex questions his future in plastics. George and Addison work together with Noelle. Noelle is pregnant with twins but one of them is growing slower than the other. Her fiancé has problems of his own. Derek's sister visits. A patient's wife makes things hard on the staff since she has made her husband's health her job. A woman's sexual exploits are questioned.

Tonights guests include Rosie O'Donnell and Lady Sovereign.

Sam and Dean investigate the slayings of blonde women and find that the ghost of the first known serial killer in US history is responsible. Jo disobeys Ellen's wishes and follows them along, and is captured by the ghost.

Tonight Stephen welcomes political activist Ronald Reagan Jr.

It's Diwali, The Hindu Festival of Lights, Michael encourages the entire Scranton branch to support Kelly and attend a local celebration of Diwali. Meanwhile Ryan faces Kelly's family at the event.