The Cadillac of an infamous 1970’s mob boss turns up in a lake, even though he disappeared years ago. A photo of current murder victims also turns up in the car, so the team must determine whether this current murder spree is related to the missing gangster.

A traumatic car accident fills the ER. Izzie pushes the boundaries of her probation. Cristina has a crisis of conscience about her deceptive teamwork with Burke.

Dave shows footage of the staff Thanksgiving dinner, which includes a drunk Biff telling off Dave and a turkey carver severing his hand; Dave correctly guesses that his mother made pumpkin pie but flubs on the next dessert (he said pecan, it was apple); John Mayer performs "I'm Gonna Find Another You."