Recent events strain Burke and Cristina's relationship. Mark and Derek must work together when two close-knit brothers seek medical help. One of Meredith's half sisters is admitted to the hospital.

Tonights guests include Jennifer Connelly, Tom Dreesen and Shiny Toy Guns.

Tonight Stephen welcomes ESPN commentator and author of "Miracle on 49th Street", Mike Lupica.

Michael tries to be supportive when he finds out one of his new employees -- presumably someone from the Stamford branch -- has a prison record.