Meredith discovers that Derek has a problem sleeping while her father comes to visit the hospital. George's father is moving from one surgery to another. A patient named Heather checks into the hospital. Heather is 17 and has a nasty attitude that results from her medical condition and all the surgeries it has required her to have. Izzie has an emotional breakdown when she tries to hand over something very important to her. George's family comes to visit to celebrate his father's surgery. Cristina and Burke are playing Uncle.
Videotape operator Tom Catusi apologizes for making a cheap shot at Mark McGwire; Madonna discusses her controversial adoption of a Malawian baby; Dave puts on a raincoat and promotes Gordon's Fish Sticks; The Hold Steady performs "Stuck Between Ready."
Stephen starts with another episode of his challenge "What Number is Stephen thinking of?" with a clip from 2005. He then celebrates 5 years of Guantanamo Bay and talks to the executive director of Human Rights Watch, Ken Roth. After that he does a "Tip of the Hat/Wag of the finger", double-wagging Apple (claiming this is his first double-wag) for 1) changing their name to "Apple, Inc." and 2) bringing out the iPhone.
It's time for Michael to revisit his roots with the company as he hits the road for sales call duty. Meanwhile, Dwight attempts to cover up a crucial deadline missed by Angela while Karen is in for some surprising news.