Grissom and his team are discouraged when they find a pool of blood as they begin investigating the disappearance of a high school basketball star and his cheerleader girlfriend. Grissom's quip that the young lovers may have run off to Mexico is soon quashed by the discovery of drops of blood by Ryan's vacant parking spot at the school. After finding a letterman jacket and cheerleading sweater in the field house and a pool of Ryan's blood nearby, the team tries to determine what went awry.

Everyone is pushing for Meredith to survive, or in this case to be revived. People are still dealing with the fallout from the ferry disaster. A young man named Lucas is having problems with brain-mouth coordination. Someone else dies.

Michael and Jan reveal their hushed romance while attending the Dunder Mifflin CFO party. During the party, Jim finally meets Karen's ex. Meanwhile, the rest of the office staff booze it up during happy hour.