Alex grows closer to Jane Doe as he continues to work on her case. Helen Crawford flies into Seattle for surgery. She knows someone on the staff. Colin Marlow enters the race for Chief of Surgery. George faces more problems with Callie and Izzie. Callie reveals a big secret. Someone treats a WWII veteran. Also Derek treats a patient near and dear to him.

Callie's father comes to Seattle Grace and meets George, the hospital starts interviewing candidates for the Chief's position, and Alex helps Jane Doe figure out her place in the world. George and Izzie have a few morning-after symptoms.

A fatal automobile accident from 1992 leaves an angry apparition haunting a remote stretch of highway, and Sam and Dean try to lay it to rest.

Stephen celebrates the last St. Patrick's Day ever! Then he moves on to how Latin America has so many rabid admirers of President Bush, with comments from Esteban Colberto. In the 44th installment of Better Know A District, the guest was Phil Hare of Illinois's 17th congressional district.