Colin Marlow continues to try to get in the way of Cristina and Burke's relationship. The daughter that Izzie gave up for adoption needs something from her. This episode features a pro chess player, a flirtatious woman, and a mother named Mrs. Malone. Mr. and Mrs. Malone haven't talked to their daugther in a while because of their son-in-law. Someone goes to see a priest.

Sam and Dean discover that a group of ghosts are attempting to shut down production of a movie that they feel is mocking them.

Stephen balks at a scientific study saying that chimpanzees are more evolved than humans in DNA. On "The Word," he talks about John Edwards' $400 haircut and considers him going over to the Republican party. Colbert then interviews Sean Penn, and leads to a Meta-Free-Phor-All hosted by Pinsky (the decider of topics for the rounds used humorous pictures and sound effects in the style of The Daily Show's "God Machine," which Colbert usually took part in).