Hodges stages hypothetical murders in the lab in order to give his fellow lab techs a chance to play CSI, but unbenownst to them he has other motives behind his actions. Meanwhile, after Sara's farewell, everyone tries to comfort Grissom.

An ambulance crash endangers the lives of the paramedics involved, as Meredith and the Chief work on-site to save them, Bailey treats a patient who refuses her help, and Ava returns for Alex and meets his other girlfriend in the process.