The team investigates an underground mob. Warrick ends up becoming the prime suspect in a murder that's related to the mob, and his addiction to pills starts to have a significant impact on his job as a CSI.

Meredith works furiously to save a paramedic trapped in an ambulance; Lexie holds the life of a patient in her hands; Derek must rely on a nurse to save a patient; Bailey struggles to balance her personal life with her work.