While fielding a question about Oprah tickets, Dave accidentally breaks one of his pencils in half; a certain panicky audience member is confronted by Dr. Phil in the theater hallway; Kate Walsh shows off her new puppy; Jason Sudeikis discusses his famous uncle; OK Go (featuring Bonerama) performed "A Million Ways."
Stephen begins with congratulating Barack Obama winning a Grammy award for "Best Spoken Word Album" for The Audacity of Hope: Thoughts on Reclaiming the American Dream. He then talks about Mitt Romney dropping out of the race for President. He then interviews Aubrey de Gray about defeating aging and trying to make John McCain young. Stephen then talks about his portait to Marc Pachter (over the telephone). Pachter tells him that the portait has increased the number of visitors to the museum and that it will now be displayed in the National Portrait Museum until April 1. He then interviews Philip Zimbardo about "The Lucifer Effect" and how people become evil.