Steve is left home as the family plan a trip to Boston hoping to locate a college for Hayley. When his friends arrive they convince him to break the rules, resulting in them finding the controls to a military drone in Stan's study. Meanwhile, after Stan leaves the plane to return home for his painkillers, Roger changes disguise from a little girl to a Stan constume so he can get served alcohol. When an air marshal notices that the girl is missing, he grounds the plane and investigates.

Stewie and Brian are suspicious when two guys move into Cleveland's old house, and when they find out Dan (guest voice Dan Aykroyd) and Chevy (guest voice Chevy Chase) are spies and they have dossiers of all the people in Quahog they follow them on a mission to Russia and end up in hot water.

There is trouble for Don and Sal in giving their clients what they ask for. Meanwhile, Betty hosts a fundraiser.

Mixed martial arts (MMA) gains popularity in Springfield, and Marge leads a protest against it. The promoter of a local MMA company decides to gain publicity from the controversy by challenging Marge to a match, with the promise that he will shut down if she wins.