In the 150th episode, Brian & Stewie get locked in a bank vault, they are forced to deal with each other on a whole new level. Unlike any other FAMILY GUY episode, the acts will play out in real time as Brian and Stewie react to being locked in a small space with no baby food or martinis to keep them from losing their minds while they hatch an escape plan.

A bomb squad mistakenly blows up Homer's unattended gym bag, releasing radiation into the city and authorities react by suspending civil liberties. Wiggum and his men install surveillance cameras around Springfield and round up suspected terrorists, including groundskeeper Willie, but when monitoring the nonstop flow of video imagery proves to be too much, Wiggum enlists concerned citizens to help keep the city safe. Meanwhile, Lisa becomes fed up with being blonde, so she dyes her hair a dark color.