When Kiera and Carlos investigate two mysterious murder-suicides, they quickly realize that both may be the result of a lethal computer program turning video game programmers into killers.

Ben is endangered by someone who he thought he could trust. Tom captures another hostage. Weaver offers Matt a job to lift his spirits. The 2nd Mass are trapped in a basement and face a new enemy.

When the co-owner of a luxury medical spa turns up dead, Jim and Jennifer investigate the spa's members and discover the high costs the wealthy pay in order to stay looking young and beautiful. Callie gets anxious while both studying for her boards and preparing for her testimony against Elkins. Her house in Palm Glades is falling apart, but her life in Atlanta is picking up.

News of unrest in Wisconsin in February 2011 in response to the governor's call for budget cuts bubbles up during coverage of the ousting of President Mubarak in Egypt, and Neal finds someone who can provide updates from Cairo as the staff strive to give equal attention to both uprisings.