After sales for their hangover cure are slower than expected, the guys decide to take part in a drug trial for quick cash, but their plans are unexpectedly derailed by Paula Abdul. Meanwhile, Kelly faces an awkward situation after spending time with Leslie and Josh.

When their bank accounts begin to run dry, the Griffins look for ways to make money. Stewie gets cast in a peanut butter commercial and becomes the money maker for the family. Meanwhile, Lois and Peter become crazy show business parents and Brian helps Stewie realize that he does not want to be a child actor.

Elizabeth tries to salvage a peace deal with Russia after an unexpected turn of events threatens to dissolve the agreement. Also, Elizabeth gets dragged into dealing with an emergency situation aboard the International Space Station.

Frank's newfound appreciation freaks the Gallaghers out.

Tensions run high as the entire Florrick family is crammed into Peter's campaign bus with Eli and Ruth on their way to the Iowa Caucuses. Once there, Peter attempts a high-risk political stunt to gain votes for his presidential bid.

There is a new teacher at Springfield Elementary, and a captivated Bart tries everything to win her over. Meanwhile, Homer decides to buy a new brand of “milk,” which causes early puberty, both for Bart (augmenting his wooing powers) and Lisa (whose small bout with acne opens her up to the world of makeup and popularity).