An ex-NYPD officer goes missing the day after she reveals to Danny her plans to make amends to the woman she and her partner wrongfully convicted years ago. Frank faces a dilemma when one of his peers refuses to retire.

In the series finale, Nick faces off against his greatest foe yet as it seems no weapon can defeat him. At the Spice Shop, Monroe, Rosalee and Eve search for answers and stumble upon a rare potion that may help the fight. Elsewhere, Capt. Renard and Adalind try to keep Diana and baby Kelly safe as the threat has its eyes set on the children.

Mac and Jack help Mac’s close friend from M.I.T. after she fakes her own death to prevent someone from killing her in order to suppress her scientific research.

When Darnley gets a surprise visitor, his marriage to Mary hangs in the balance. Elizabeth learns her attempt to stop Mary backfired. Meanwhile, Catherine and Narcisse find King Charles and must convince him to return to the castle.

Dreyfuss finally garners enough power to infiltrate the White House, and his group of minions grow strong enough to take action. Can Team Witness stop Dreyfuss in time?