In the apocalypse of 2163, a desperate Cole searches for Titan. Meanwhile, a captive Railly is faced with an impossible choice as the 12 Monkeys await the arrival of The Witness.
Ramse and Cole splinter to 2007 expecting either a trap - or a final chance to kill The Witness. But when Cole discovers a heartbreaking truth, he’ll discover that the mission was both.
Darnley teams up with John Knox to strip Mary of her throne, which will leave a close friend of Mary's dead. Elizabeth must banish Gideon from court at the request of her future husband, while Charles takes a bold stance against his brother Henri.