Scarlett confronts the journalist Mackenzie Rhodes face-to-face. Will shoots a commercial. Deacon feels pressure from the outside to move on from Rayna.
Jordan and Cain travel to the scene of an oil-field explosion and treat a patient with extreme injuries. Also, Drew and Paul try to save a patient's severed hand; Scott encounters a person from his past; and TC tries to help a sick Syrian child.
Jackson and Logan discover a link between the hybrid attacks that occur in Portland and New York; Mitch is interrogated by a woman claiming to be his daughter, Clementine; and a new development in Abraham’s research into the sterility crisis endangers his family.