Slabside becomes even more dangerous after a guard is murdered and everyone is a suspect. Felicity enlists help from a surprising source in her pursuit of Diaz, and Laurel flexes her muscles as the District Attorney.
A new fugitive is on the loose in 1951 Tokyo and Sara, Zari, Rory and Charlie try to capture it. As Constantine struggles to recover, Ray knows that magic might be the only thing that can save him but must look outside the team for help. Meanwhile, Ava joins Nate and his family for an unconventional Thanksgiving dinner.
IMSF and Lukrum, now sharing a common water and power source, have established a tenuous coexistence that threatens to dissolve when Kurt and his crew make unexpected headway in their mission to mine the planet, and Hana works to maintain diplomacy between the two camps—until tragedy strikes. Meanwhile, on Earth, Dr. Leslie Richardson asserts her authority as the new IMSF Secretary General. In present day, Greenpeace activists take to the seas to protest Arctic oil drilling in the Barents Sea, and the effectiveness of such tactics are examined.
Dr. Shaun Murphy, Dr. Audrey Lim and Dr. Claire Brown's E.R. patient is forced to reveal a secret to her husband after their treatment caused a complication. Meanwhile, Dr. Neil Melendez, Dr. Morgan Reznick, and Dr. Alex Park struggle with a patient whose parents don't believe in vaccinations.