Amidst a shifting political climate, Frank goes head to head with City Council Speaker Regina Thomas over protests against police brutality. Jamie and his nephew Joe Hill work together to locate Danny and Baez when they go missing while searching for a killer. Eddie steps up to help an abrasive woman find her father's body after it was misplaced during the outset of the pandemic.
Mac and the team infiltrate a glamorous hotel used as an international hideout for criminals to find a woman with vital information on Codex. However, their target has a new secret identity, including a completely new face.