The Reagans confront hard choices on the job when Frank deals with a police captain who's losing his grip over his precinct. Danny faces backlash from Baez and Internal Affairs over a tough call he made in the field. Jamie and Eddie are shown the ropes of field crisis management when a social worker is assigned to them for a ride-a-long. Erin weighs the consequences of a dangerous criminal's release under new bail laws.

The secret experimental cancer treatment Mac’s developing with a friend is discovered when culprits ransack their lab, kidnap Mac’s partner and plan to use the research to create a powerful new nerve agent.

The task force investigates an organization of bank robbers with a special expertise in stealing from other criminals. An old blacklist case resurfaces.

Dolly Parton, Noah Centineo and Jimmy take turns confessing a random fact in a brand-new True Confessions, then Jimmy chats with Parton and Centineo before welcoming musical guest slowthai ft. Skepta.