After Danny witnesses a drive-by shooting, he butts heads with the detective assigned to the case. A childhood friend of Jamie's is convinced that she has single-handedly solved a cold case murder. Frank struggles to trust an ex-detective when he brings forth information about a suspected crime ring.

Mac and team rush to help when Matty’s former mentor, Ian Cain, and his embassy staff come down with a deadly, mysterious illness. Taylor and Bozer work with Jerry Ortega to infiltrate a Codex cell.

Red and Dembe go to great lengths to fulfill the final wishes of a dear friend. Aram goes undercover as an interpreter to a company that provides services to criminals. Park helps a friend in trouble.

Jimmy takes a moment to write out some Thank You Notes, challenges Kenan Thompson to guess iconic movies and TV shows in five seconds or less, catches up with Lana Condor and welcomes musical guest Fireboy DML.