A call to a familiar location brings back mixed emotions for Severide. Herrmann heads out for a vacation. Casey is not thrilled with his replacement.

The citizens of South ParQ are clamoring for the COVID-19 vaccine. A hilarious new militant group tries to stop the boys from getting their teacher vaccinated.

Jimmy takes suggestions from the audience in a new Audience Suggestion Box, then catches up with Norman Reedus and Charli and Dixie D’Amelio before enjoying stand-up from comedian Mike Vecchione.