Danny partners with Texas Ranger Waylon Gates again to deliver an infamous drug cartel boss to arraignment, but the mission becomes complicated when the criminal threatens to harm the Reagans. Also, Erin is thrust into the spotlight when she takes on a highly contentious assault case involving a beloved basketball star; Eddie forms an unlikely alliance to solve a cold murder case; and Frank and Jamie clash when Frank denies a request for Jamie to go undercover.

Jimmy pens his weekly Thank You Notes before speaking with guests Lucy Liu, Damson Idris, Bizarrap and Shakira and welcoming musical guests Bizarrap and Shakira.