Viewers’ favorite myths are put to the test. If you sneeze with your eyes open, will your eyeballs pop out of your head? Can you stop a car by putting it in reverse? Will a tennis ball unlock a car door? Also, Jamie and Adam reunite with Alan Normandy to test whether you can kill someone by loading your rifle with cigarette butts. And finally, a young boy asked the MythBusters to take care of the family station wagon. Retired FBI agent Frank Doyle and friends lend their support…and munitions.

From the previous episode, Stephen again mentions the possibility that his ancestors were Jewish. He then discusses perceived inflammatory speech on the Daily Kos website and interviews the website's founder, Markos Moulitsas. In the "Monkey on the Lam" segment, Stephen talks about a capuchin monkey that picked the lock on his cage door at a zoo in Tupelo, Mississippi for the second time in two weeks. He then discusses Attorney General Alberto Gonzales' failure to meet his potential. Finally, Stephen interviews Michael Wallis about the Lincoln Highway.

The chefs are told that they must create the perfect burger. Then, they must create a new restaurant concept, including a great menu. Chef Daniel Boulud is the guest judge.