In the 100th episode, Booth and Brennan tell Sweets about a mistake in his book. Sweets is shocked to learn of this mistake, and asks Booth and Brennan to reveal the truth. They agree, and flash back to the first time they worked on a case together. The formation and evolution of their relationship, as well as the relationships of the other Jeffersonian workers, is examined.

When the CSI team investigates the brutal murder of a family, they trace the killer to the house next door, which might belong to the "Dr. Jekyll" serial killer.

Sam and Dean are outnumbered by demons, but are saved at the last minute by Rob and his townspeople, who are aware of the Apocalypse, and have been training to fight and kill demons. The small town is very religious and Sam and Dean meet Pastor Gideon, who introduces them to his daughter Leah, whom he claims is a prophet. Leah tells the townspeople they must obey her orders if they want a spot in Heaven but when she starts turning the townspeople against each other in the name of the Lord, the brothers realize they must kill her.

Tonight Stephen welcomes astrophysicist and the director of the Hayden Planetarium, Neil DeGrasse Tyson

Tonight's guests are actress Jennifer Love Hewitt and author Stuart Neville.

When a "Jane Doe" with amnesia and covered in blood steps in front of Cho and Van Pelt's car, Patrick Jane must use all of his skills to discover who she is, her last location and why she lost her memory

When Stefan and Damon make a dangerous new enemy, Stefan suddenly finds himself in a perilous situation. Damon and Elena try to convince Alaric to work with them to help Stefan. Matt is hopeful that his mom, Kelly, may be back to stay. After her car breaks down in a storm, Caroline make a horrific discovery that shocks everyone in town.

Murder: Kevin Hughes Mystery: Padre Pio Update: Lost: Saviors of Colleen Frangione Lost: Deborah Poe Lost: Bill and Cynthia Zelinski

Mystery: Chad Maurer Wanted: Robert Fisher Legend: Agatha Christie Lost: The Friends of Fritz Vinchen