A cabin burns down in the woods revealing two bodies, one of a modern-day witch and one from the days of the Salem Witch Trials leading Booth and Brennan into the world of Wicca to find a killer. Meanwhile, when Hodgins' reckless driving gets him and Angela arrested and thrown in jail, Sweets and intern Clark Edison step into unfamiliar territory to help out the team.

The sexual tension between Jeff and Britta becomes a hot topic in study group. A contest for a chance at early class registration turns the peaceful campus of Greendale Community College into an all-out war zone.

A mother thought to be grieving for the loss of her family three years ago becomes a suspect in a CSI investigation.

Bailey preps the team with mandatory sensitivity training prior to admitting a 700-pound patient with compounded medical issues, and the case proves to be challenging in every sense of the word. Meanwhile Derek has to come face to face with a former patient's husband in a wrongful death deposition, and spending time with a heart patient's daughter opens up some old wounds for Cristina.

Journalist Brian Williams; author Beth Ostrosky Stern; Court Yard Hounds perform.

Leslie hosts a late-night shift for a local telethon, and lands former Indiana Pacer Detlef Schrempf as a celebrity guest. Meanwhile, Mark has big plans for his relationship with Ann.

Crowley tells Bobby he will give him the location of Death, the fourth horseman, in exchange for his soul. Knowing Sam and Dean need that fourth ring to stop the Apocalypse, Bobby reluctantly agrees. Sam and Dean confront Pestilence, but he unleashes a deadly virus upon them, so Castiel must intervene on their behalf. Dean has a meeting with Death to discuss Lucifer, and an unholy alliance is formed at a very high price for Dean.

Tonight Stephen welcomes environmentalist and author of Whole Earth Discipline: An Ecopragmatist Manifesto, Stewart Brand. Also, Stephen talks with The Atlantic Monthly columnist Andrew Sullivan about the British elections.

Tonight's guests are actor Mark Harmon, actress Sophia Bush, and a performance by Local Natives.

Patrick Jane and the CBI team investigate the death of a mathematical genius by a gun-wielding clown.

Michael suspects Donna is cheating on him and puts P.I. Dwight Schrute on the case. Meanwhile, Andy is frustrated when no one takes his customer's complaint seriously.

Isobel returns to town and stuns Alaric with her attitude and her demands that he arrange a meeting with Elena. When mother and daughter finally meet, Isobel refuses to answer most of Elena’s questions, but reveals that she will stop at nothing to find the mysterious invention Johnathan Gilbert has been searching for. Isobel’s dangerous actions lead Stefan, Damon and Bonnie to step in and help Elena deal with the situation.