New roommates Troy and Abed host an apartment-warming party that takes a strange turn.

The residents try their hardest to impress surgical great Catherine Avery-who also happens to be Jackson's mother-when she arrives at Seattle Grace to perform a groundbreaking transplant surgery; Arizona and Alex find their hands tied with a confidentiality issue when a familiar patient comes into the ER; meanwhile, a love-struck Teddy throws a dinner party for the couples, and Bailey makes a decision regarding her love life

When Frank's long lost brother Gino shows up at the bar, the two of them tell the gang about the jazz club they ran in the 1960s and 70s, and how they fell out over Shadynasty, a singer who was the love of both of their lives.

Dave welcomes talk show host/author Bill O'Reilly and musical guest Martina McBride.

Dara O Briain and the regulars relive the week's events for the last time in this run with guests Milton Jones, Miles Jupp and Andi Osho.

Ron takes his boys-only troop of Pawnee Rangers into the wild. Not wanting the girls to feel left out, Leslie also takes her troop of Pawnee Goddesses on an adventure weekend. Meanwhile, a reluctant Ben joins Tom and Donna for a day of relaxation, and Chris spends some time with Jerry.

Reese and Finch try to unravel a threat to a promising young doctor.

Sheldon and Leonard get invited to a party at Wil Wheaton's house, and Howard gets an out-of-this-world opportunity.

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Everyone is disappointed with their draft, but no one trusts each other enough to trade. Jenny goes back to work as a realtor. Ruxin tries to get Baby Geoffrey into a Jewish pre-school.

While Lisbon looks into the death of a photographer at a political rally, Jane has his sights set on proving a man carrying a gun at the same rally is a psychopath with murder on his mind.

Andy plants the seeds of trying to impress Robert California by throwing a garden party at Schrute Farms. Andy's parents and brother also attend the event, only to make him feel awkward.

Despite all that has happened, Caroline is determined to see that Elena, Bonnie, Matt and Tyler all enjoy a traditional Senior Prank Night before the school year begins at Mystic Falls High School. However, when uninvited guests show up, it doesn't take long for the evening to take a deadly turn. Damon convinces Jeremy that he can use his new connection to the other side to help find a way to defeat Klaus. Finally, Klaus deepens his hold on Stefan and uses him for increasingly violent and dangerous purposes.