Detective and family man John Lowe investigates a chain of gruesome murders in Los Angeles. A mysterious tip points him to the enigmatic Hotel Cortez.

Oliver and Felicity’s blissful getaway is cut short when Thea and Laurel pay them a visit and tell Oliver they need his help back in Star City. The city has been attacked by “Ghosts,” assassins led by a dangerous man named Damien Darhk. However, when Oliver returns, Diggle makes it very clear that he doesn’t want Oliver on the team.

After Dre gets his yearly physical and comes home traumatized, Pops explains his generation’s strong aversion towards healthcare and admits that he hasn’t seen a doctor in years. Shocked by this disclosure, Dre and Bow try to convince Pops to get a check-up and he begrudgingly agrees. When Pops finds out he has a clogged artery and needs a small procedure, the rest of The Johnson family handles the news in different ways.

Christa saves a woman's life and then pleads with Neal to perform a surgery that will save the patient's reproductive future.

When a Los Angeles bus is attacked with sarin gas, the BAU must act quickly to find the suspect before a larger-scale incident occurs.

Anika secretly work together behind Lucious’ back to pull off a surprise performance that catches the eye of Pitbull. Meanwhile, Lucious tracks down Frank Gathers’ daughter, Young Ma, to try to convince her to sign with him at Empire, while Hakeem is hard at work on his girl group, Ménage a Trois. Also, Andre and Rhonda hope their baby-on-the-way will be the key that unlocks Lucious’ cold heart and opens the door for Andre to return to the Empire fold.

A starving toddler found wandering the streets alone leads detectives to the home of Manuela Ozuna and another child in grave condition. The police question Department of Child Services caseworker Keith Musio, whose vague and backdated reports on the family suggest he hadn't checked on the children in months. When the overworked Keith accuses his supervisor, Janette Grayson, of orchestrating the false reports, Chief Dodds promises to conduct an internal investigation. But when neglect leads to death, Barba takes matters into his own hands and arrests them for manslaughter. Meanwhile, Dodds indicates some changes coming to Benson's squad.

Mitchell takes a job with a rival of Jay’s; Luke and Manny visit Alex but use the opportunity to meet girls; Gloria is upset when a cheerleader doesn’t decorate Manny’s locker; Phil and Claire try to play chicken when Dylan moves in.

A second aneurysm leaves Beverly brain dead and Deacon consumed with guilt, while Scarlett is forced to decide whether or not to keep Beverly on life support. Meanwhile, Juliette continues a destructive pattern of erratic behavior, pushing Avery to make the heart-wrenching decision to file for divorce.

Picking up where the finale left off, Sam and Dean must deal with the Darkness that has been unleashed. Castiel deals with the effects of Rowena’s spell and recalls his brutal battle with Crowley.

Kevin is uncomfortable with Ellie's new sex-ed class. Taco starts a Little Eskimo Brothers program at the EBDBBnB.

Frankie is shocked when Mike trades in his flannel for a Hawaiian shirt; and Sue accidentally tells Devin that Axl loves her, leading Devin to question their relationship. Meanwhile, Brick gets overambitious while cleaning the bathroom.

Kate Winslet (Steve Jobs (2015)); Norman Reedus (The Walking Dead (2010)). Also: Jimmy presents kids' inventions.

Jimmy questions his ability as a writer but finally zeroes in on his next project. Meanwhile, Gretchen and Lindsay discover all they do is talk about men and set out to change the status-quo. Edgar gets close to his improv teacher, Dorothy.