On Brennan and Booth’s first official day back at their respective positions at the Jeffersonian and the FBI, things get exciting when remains are found at a fish farm under suspicious conditions, prompting them to investigate. After it’s discovered that someone harvested several of the victim’s internal organs before he was dumped in the water, Angela tracks down the seller and buyer of the organs to try to uncover important details in the case. Meanwhile, Booth readjusts to his position back at the FBI and discovers Aubrey has taken over his old office; Hodgins pushes Angela to showcase her photography work; and Cam struggles with her decision to choose work over her relationship with Arastoo.

Owen suggests the interns learn a vital lesson on how to break bad news to patients’ families, and Arizona’s 90-year-old patient reassures her that she’s destined to find love again. Meanwhile, the sisters completely forget about the dinner party they’re hosting for everyone.

Dwight and Charlotte work to clear Nathan's name when the citizens of Haven put the lawman on trial. Hoping to buy them time, the brothers Teagues moderate the courtroom proceedings, while Audrey continues her quest to solve the darkness troubles.

Noah and Quentin take on Renautas. Miko's plan to retrieve her sword may land her in trouble. Malina's journey bring her closer to the truth. Luke returns home to confront his past. The authorities close in on Tommy. Carlos may have found an unexpected ally and Erica solidifies her plans.

When a teenager is found murdered in the woods, Annalise and her team is hired to represent an unlikely suspect named in the case. Asher comes across a shocking confession, and Wes learns new information about Rebecca’s disappearance.

The man responsible for Alex's brother's drug problem is admitted to the hospital.

Eager to get answers, Jake unexpectedly crosses paths with someone he thought he’d never see again. Meanwhile, Huck and Quinn recruit a familiar face to help smooth over the media storm surrounding Olivia, and Fitz quickly finds out the true cost of mercy when he discovers not everyone fully supports his actions.

Fear is rampant in Sleepy Hollow when Pandora releases an ancient artifact from her box that can transform an ordinary human into a terrifying figure from the past.

Liz and Red take a detour towards the Midwest as part of their mission to exonerate Liz and defeat the Cabal. Ressler, Samar, and Aram continue to track the fugitives and in the process stumble upon what could become a global food crisis. Meanwhile, Cooper turns to an unlikely ally.

Pentatonix performed the opening theme; Tonight Show Superlatives; Tonight Show #hashtags: #WhyDidISayThat; Tonight Show Kid Theater (Tom Hanks); Pentatonix performed "Can't Sleep Love"

When an impulsive decision by Damon threatens to unravel a carefully negotiated deal between Stefan and Lily, he has no choice but to make amends with his mother before things spiral further out of control. However, Lily remains one step ahead and carries out a harsh plan that hits Damon where it hurts most. Elsewhere, after returning to Whitmore Collage, Alaric turns to Bonnie for help with a mysterious and potentially dangerous artifact he has obtained, while Matt is forced into making a risky life or death decision. Meanwhile, Caroline, who finds herself a pawn in Lily and the heretics' plan for retribution, uncovers a shocking detail about Stefan's past.