John closes in on The Ten Commandments Killer. Sally’s arrangement with March is revealed.

Oliver and Barry Allen take Kendra Saunders and Carter Hall to a remote location to keep them hidden from Vandal Savage while they figure out how to defeat him. Malcolm arranges a meeting between Vandal, Green Arrow and The Flash that doesn’t go as planned. Meanwhile, Felicity, Thea, Diggle and Laurel work with Team Flash to come up with a weapon powerful enough to destroy Vandal Savage. This cross-over episode began on The Flash's season 2 “Legends of Today” episode.

Dre has always looked out for the crew he grew up with, but when his childhood friend Sha comes to stay at the house for a few days, Bow thinks he is taking advantage of Dre. Meanwhile, Daphne Lido, the now ex-wife of Stevens & Lido’s founding partner, gains control of half of the company and wants to start inserting herself in company business. When Daphne starts to question Charlie’s work ethic, Dre must decide who he remains loyal to.

The ER adjusts to the new department head who questions Rorish's decisions. An ambulance arrives with its paramedics knocked out by their patient, who attacks Jesse. Later, Jesse has a heart attack. As the doctors try to save him, other patients include a man hit by a train, the daughter of a controlling Beverly Hills mother, and the wife of a veteran who is struggling with addiction. Meanwhile, Mario leaves the hospital to find the train victim's son with intellectual disabilities, against Hudson's orders.

After two undercover DEA agents are murdered and a third goes missing, the BAU joins the NSA to investigate whether an underground Internet drug syndicate is involved. Also, Hotch hopes the team’s work with the NSA brings them closer to finding the “Dirty Dozen” hitmen ring.

Lucious makes a reckless play for the streaming service that he believes will make him the most powerful man in music, only to learn that the entire business strategy was part of a scheme that might bring Hakeem’s ex, Camilla, back into the picture. Meanwhile, Cookie decides to plan a concert at the prison where she spent 17 years locked away from her family and a tragic “accident” leaves Rhonda in a scary state.

Alvey and Lisa open Navy St. up for a showcase, inviting sponsors into the gym to see Alicia in action. Ryan and Jay, knowing this could be their last opportunity to evade Alvey's attention, enjoy a cheat day.

Gloria wins a silent auction to have a therapist come for an afternoon with the adults; Haley and Alex consider dumping their boyfriends.

Rayna’s new artist, Markus Keen, causes trouble for her when he scraps a song on his new album one week before its release. Is Deacon part of the solution or the problem? Luke attempts to reconcile with Colt, and Scarlett surprises Caleb back in Nashville when she gets time off on her tour

Pops and the gang try to win a game show.

The latest news in the school paper sends the boys searching for their missing classmates.

Sam is shocked when his childhood imaginary friend Sully makes an unexpected appearance. Sam can’t understand why he’d see Sully now but what’s even more surprising is that Dean can see him, too. Flashbacks reveal young Sam’s friendship with Sully and why he needed him.

The league is kicked off their fantasy football website, so Kevin runs the league old school. Jenny deals with loss. Rafi counsels Ruxin. Andre tries to co-opt Ruxin's dinner reservation.

Frankie invites Mike to join her on a trip to Des Moines, Iowa for a convention about her dentist office's transition to a new owner; and Axl informs a disapproving Sue that he's moving into her dorm room. Meanwhile, Mike's dad agrees to watch Brick while the parents are out of town.

Adam Driver (Star Wars: Episode VII - The Force Awakens (2015)); former NFL quarterback Brett Favre; Lenny Clarke performs stand-up. Also: Jimmy presents kids' inventions.

Top chefs arrive in Los Angeles in the opener of Season 13, which will feature the foodies competing in six cities across California. Here, they try to wow food critics and reporters under the Hollywood sign.

Gretchen’s depression comes to a head, forcing Jimmy to make a tough choice. Lindsay finally lets Paul go. Edgar has his improv graduation show.