Elena struggles to deal with a new discovery about her past. Clay readies Stonehaven for a possible attack from the Spanish by calling in new Pack members. Little does he know that one of them is a traitor. Meanwhile, Jeremy and Nick find a clue at the Spanish hideout that ultimately leads to them rushing back to Stonehaven.
Erin is overwhelmed with guilt after a man she set free is accused of killing a cop. Also, Frank and Mayor Poole continue their game of political chicken over Frank’s reappointment as commissioner, and Danny and Baez investigate a case of a cop who has gone AWOL.
Monroe gets a call from a relative in Germany that will bring Nick closer to his ancestors. Things get complicated when the nefarious group Black Claw is also after the same artifacts. Elsewhere, Capt. Renard helps a mayoral candidate get an edge on his opponent. Meanwhile, Trubel confronts Eve about Nick and Adalind.
Pritchard and Duval must stop a killer who mutilates and disfigures his victims. As Pritchard and Mary grow increasingly close to one another, Otto feels resentment and wants to find a new donor.
As Abbie, Crane and Jenny struggle to find normalcy, The Kindred reemerges as a new threat. While the team attempts to figure out why The Kindred has turned to evil, Crane finds that his romantic encounters with Zoe may have caused long-lasting trouble.
When complications from her supernatural pregnancy leave Caroline's life hanging in the balance, Stefan and Valerie take extreme measures to try and save her and the babies. Meanwhile, after uncovering a dark secret about Damon, Enzo uses the information to force Damon into helping him track down Rayna Cruz, a ruthless vampire hunter who is on the loose. However, when Damon's actions inadvertently put everyone he loves in Rayna's path, he is forced to make things right before it's too late.