Following a brutal attack in the woods, Nick and Hank stumble upon a terrifying Wesen disease that may be the inspiration for the modern-day werewolf myth. Meanwhile, Adalind is offered an uneasy alliance that may help her get back what she wants most. Elsewhere, Eve's investigation uncovers a surprising revelation.
Pritchard and Duval race against the clock to save Gracie from Connor and Otto's life-threatening experiment. But time is quickly running out for Pritchard, as well, since there is no tank in which he can regenerate. Meanwhile, Mary, with the help of Alexa, does everything she can to try and unlock the code to save Pritchard's life before it's too late, and Otto wrestles with his conscience and the decisions he's made that have changed lives forever
As The Hidden One grows stronger, Crane must examine his past with Betsy Ross to find the key to stopping him. Meanwhile, Jenny wonders if she can ever have a relationship with her father, and Abbie faces a hard decision as things with Reynolds become more strained.
In the company of comedian Rob Delaney, Richard Ayoade packs his carry-on case and sets off to enjoy an optimal two-day mini city break in Seville, southern Spain. On arrival, the duo soon learn to dance flamenco and eat tapas and churros. They also explore Metropol Parasol, one of the boldest pieces of modern architecture in Europe and visit a film set built for the spaghetti western A Fistful of Dollars. After seeking to channel their inner Eastwood, the amigos repair to the saloon for some Fanta and a Kinder egg.