Nurse Crane and Trixie investigate when a mother abandons her children at the clinic, fearing they were being abused or neglected. Her husband admits that she has been behaving strangely lately, and when she is referred to a neurologist by Dr Turner, the truth proves devastating for the whole family. Christopher admits that Alexandra has been unhappy since his divorce, and Violet and Fred organise a beauty contest to raise money for charity. Valerie and Magda both sign up and quickly become close friends - leading to the sharing of a terrible secret.
Spoiler Alert! Milo Ventimiglia, Mandy Moore, Glenn Ficarra and John Requa discuss Jack's death, the fire that changed everything and "Super Bowl Sunday."